SINCE World War II, medical science has progressed to some stage where competitive medications are around for treat exactly the same ailment in different people. This isn’t nearly brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall look at the various factors that decide your selection of a selected drug.
Safety: The subsequent sub-criteria should be considered beneath the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective can be a particular drug even if it has certain side-effects so long as the acuteness in the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the opportunity side-effect of addiction.
* Long-term safety: directory could be safe in short-term treatment, but how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and a lot of chemicals answer make a different chemical, which has an effect that may harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of each other, have certain effects on one or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for its metabolism. This will cause more the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually make the same effect on exactly the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the medicines are more intense.
Tolerability: A drug could be effective and not tolerable by all patients. Example: Allergies to certain drugs in some people. Short-term and long-term tolerability must be taken into account. Efficacy: A drug just isn’t equally good at all patients. By way of example, some patients with depression or anxiety attacks experience rest from escitalopram, but there are numerous who don’t, who therefore must be prescribed an alternative anti-depressant. The interest rate of beginning of therapeutic action is a vital step to be regarded too.
Cost: Cost does not mean the price tag on acquisition of a specific medicine alone. It will also cover the price tag on treatment of a complication that may arise while using an alternative drug. Example: Inside a person who insists on taking alcohol yet should be treated for depression is normally administered an SSRI drug because they drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (such as tricyclics) may cause a brand new condition in such patients, which may need a different and expensive treatment. Therefore, it’s preferable to prescribe the more expensive escitalopram instead of a cheaper tricyclic such patients.
Simple treatment: The easiest mode of administration is preferred. If there is an alternative between an injection and oral administration, the second is preferred if your efficacy of the modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are key point to determine simple treatment.
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