SINCE World war 2, medical science has progressed to some stage where competitive medications are available to treat precisely the same ailment in different people. It’s not nearly brands (that is a trade issue) but generic drugs (that is a scientific issue). With this report, we shall go through the various factors that decide your selection of a specific drug.
Safety: The subsequent sub-criteria must be considered within the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective is often a particular drug even though it’s got certain side-effects so long as the acuteness of the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but feature the potential side-effect of addiction.
* Long-term safety: drug could be safe in short-term treatment, but how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and a lot of chemicals respond to create a different chemical, that have an effect that may harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from one another, have certain effects on a single or even more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon for its metabolism. This makes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually produce the same influence on precisely the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both the prescription medication is more serious.
Tolerability: A medication could be effective however, not tolerable by all patients. Example: Allergies to particular drugs in some people. Short-term and long-term tolerability should be taken into consideration. Efficacy: A medication isn’t equally effective in all patients. As an example, some patients with depression or panic attacks experience relief from escitalopram, but there are many that do not, who therefore should be prescribed an alternative anti-depressant. The interest rate of beginning of therapeutic action is a crucial key to be regarded as too.
Cost: Cost doesn’t imply the expense of acquiring a specific medicine alone. It ought to also cover the expense of treatment of a complication that may arise while using an alternative drug. Example: Inside a individual who insists on taking alcohol yet must be treated for depression is often administered an SSRI drug as these drugs don’t potentiate the results of alcohol, whereas another gang of anti-depressants (like tricyclics) might cause a new problem in such patients, which may need a various and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram as opposed to a cheaper tricyclic such patients.
Simple treatment: The best mode of administration is preferred. If you have a selection between a shot and oral administration, rogues is preferred if the efficacy of both the modes is the identical. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key factor to decide simplicity of treatment.
For more information about drug go our web page: click for more