SINCE Wwii, medical science has progressed to some stage where competitive medications are available to treat the same ailment in several people. This isn’t nearly brands (the trade issue) but generic drugs (the scientific issue). In this report, we shall go through the various factors that decide your selection of a particular drug.
Safety: The next sub-criteria has to be considered within the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective is often a particular drug even when it has certain side-effects as long as the acuteness of the condition is lowered? Example: narcotic pain-killers work well in healing pain but include the potential side-effect of addiction.
* Long-term safety: directory might be safe in short-term treatment, but exactly how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and a lot of chemicals respond to make a different chemical, that have an effect that may harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of each other, have certain effects on a single or more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for its metabolism. This will cause an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually generate the same impact on the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the two medicines are more intense.
Tolerability: A medication might be effective and not tolerable by all patients. Example: Allergies to a particular drugs in a few people. Short-term and long-term tolerability have to be taken into account. Efficacy: A medication isn’t equally good at all patients. By way of example, some patients with depression or anxiety attacks experience respite from escitalopram, but there are many that don’t, who therefore have to be prescribed another anti-depressant. The interest rate of oncoming of therapeutic action is a factor to be considered too.
Cost: Cost does not mean the price tag on purchase of a certain medicine alone. It should also cover the price tag on management of a complication that may arise from using another drug. Example: Inside a individual who insists on taking alcohol and yet should be treated for depression is normally administered an SSRI drug because they drugs don’t potentiate the effects of alcohol, whereas another group of anti-depressants (for example tricyclics) could cause a brand new overuse injury in such patients, which could have to have a different and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram instead of a cheaper tricyclic such patients.
Simplicity of treatment: The simplest mode of administration is preferred. If you find a choice between an injection and oral administration, the latter is preferred in the event the efficacy of the two modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to decide simplicity of treatment.
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