SINCE Wwii, medical science has progressed to some stage where competitive medications are around to treat the identical ailment in different people. This isn’t almost brands (the trade issue) but generic drugs (the scientific issue). Within this report, we shall glance at the various factors that decide your selection of a selected drug.
Safety: The subsequent sub-criteria must be considered beneath the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is often a particular drug regardless of whether they have certain side-effects provided that the acuteness with the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but include the possible side-effect of addiction.
* Long-term safety: medication could be safe in short-term treatment, but how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and lots of chemicals react to make a different chemical, that have an effect which could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other, have certain effects using one or even more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon for the metabolism. This causes a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually make the same impact on the identical organ, thus helping the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the medicines are more intense.
Tolerability: A medication could be effective but not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability should be considered. Efficacy: A medication is not equally great at all patients. As an example, some patients with depression or panic attacks experience relief from escitalopram, but there are several that do not, who therefore should be prescribed another anti-depressant. The rate of onset of therapeutic action is a the answer to be regarded as too.
Cost: Cost does not necessarily mean the cost of buying a certain medicine alone. It must also cover the cost of treatment of a complication which could arise from using another drug. Example: Within a individual who insists on taking alcohol nevertheless needs to be treated for depression is often administered an SSRI drug because these drugs don’t potentiate the consequences of alcohol, whereas another number of anti-depressants (like tricyclics) can cause a fresh symptom in such patients, which could have to have a different and expensive treatment. Therefore, it’s easier to prescribe the more expensive escitalopram rather than cheaper tricyclic in this patients.
Simplicity of treatment: The easiest mode of administration is preferred. If you have an alternative between an injection and oral administration, the second is preferred if your efficacy of the modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key point to decide simple treatment.
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