Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors depending on each SARM’s chemical structure. As a result, SARMs result in anabolic cellular activity while avoiding most of the side effects of available today steroid drugs. SARMs have already been studied in the treatments for cancer of the breast and cachexia and still have already been used as performance-enhancing agents. Here, we evaluate and summarize the actual literature on SARMs.
Aim
To give the backdrop, mechanisms, current and potential clinical applications, as well as risks and great things about SARMs.
Methods
A literature review was performed in MEDLINE with all the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancer, benign prostatic hyperplasia, libido, and lean muscle mass. Both research and clinical tests were included.
Main Outcome Measure
To complete a review of peer-reviewed literature.
Results
Although there are currently no U.S. Drug and food Agency-approved indications for SARMs, investigators are going through the potential ways to use these compounds. Investigation has devoted to the pharmacokinetics and pharmacodynamics of these agents, demonstrating good availability which has a paucity of drug interactions. Early clinical studies have demonstrated potential uses of SARMs from the treatment of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancers, with good success.
Conclusion
SARMs have numerous possible clinical applications, with promise for that safe use within the treatment of cachexia, BPH, hypogonadism, cancer of the breast, and cancer of prostate.
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