SINCE The second world war, medical science has progressed to a stage where competitive medications are for sale to treat the same ailment in numerous people. This is not just about brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall go through the various factors that decide the selection of a particular drug.
Safety: The next sub-criteria have to be considered under the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is a particular drug even though it’s certain side-effects as long as the acuteness in the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but have the potential side-effect of addiction.
* Long-term safety: medicine directory could possibly be safe in short-term treatment, but exactly how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and lots of chemicals reply to produce a different chemical, which has an effect that will harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from each other, have certain effects on a single or higher body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon for its metabolism. This will cause a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually create the same effect on the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the two medicines are more intense.
Tolerability: A drug could possibly be effective although not tolerable by all patients. Example: Allergies to specific drugs in certain people. Short-term and long-term tolerability need to be considered. Efficacy: A drug is not equally effective in all patients. As an example, some patients with depression or panic attacks experience reduced escitalopram, but there are numerous that don’t, who therefore need to be prescribed some other anti-depressant. The pace of start of therapeutic action is a vital the answer to be considered too.
Cost: Cost does not necessarily mean the cost of acquisition of a specific medicine alone. It must also cover the cost of treating a complication that will arise by using some other drug. Example: In the individual that insists on taking alcohol and yet needs to be treated for depression is usually administered an SSRI drug because they drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (including tricyclics) might cause a brand new overuse injury in such patients, which may demand a various and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram as opposed to a cheaper tricyclic such patients.
Simple treatment: Most effective mode of administration is preferred. If there is a choice between an injection and oral administration, aforementioned is preferred if the efficacy of the two modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are a key point to make a decision simple treatment.
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