SINCE World War II, medical science has progressed into a stage where competitive medications are around for treat the identical ailment in numerous people. This is not nearly brands (that is a trade issue) but generic drugs (that is a scientific issue). On this report, we shall look at the various factors that decide selecting a specific drug.
Safety: The following sub-criteria have to be considered under the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective is really a particular drug even though it’s certain side-effects as long as the acuteness in the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but come with the possibility side-effect of addiction.
* Long-term safety: http://medicationdirectory.com may be safe in short-term treatment, but how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and many chemicals react to make a different chemical, that have an effect which could harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from one another, have certain effects one or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by for its metabolism. This makes a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually generate the same impact on the identical organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both medicine is more serious.
Tolerability: A medicine may be effective although not tolerable by all patients. Example: Allergies to particular drugs in a few people. Short-term and long-term tolerability must be considered. Efficacy: A medicine is not equally great at all patients. By way of example, some patients with depression or panic disorders experience rest from escitalopram, but there are lots of who don’t, who therefore must be prescribed some other anti-depressant. The rate of onset of therapeutic action is a vital the answer to be looked at too.
Cost: Cost does not mean the expense of buying some medicine alone. It will also cover the expense of treating a complication which could arise by using some other drug. Example: In the one who insists on taking alcohol yet should be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another number of anti-depressants (such as tricyclics) can cause a whole new symptom in such patients, which would have to have a different and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram as opposed to a cheaper tricyclic in this patients.
Simplicity of treatment: The simplest mode of administration is preferred. If you find an alternative between an injection and oral administration, the second is preferred if your efficacy of both modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are a key point to decide simplicity of treatment.
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